Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology
作者： U. Mengs , C. D. Stotzem
DOI: 10.1007/BF01973700
关键词:
摘要: The nephrotoxic action of aristolochic acid (AA) was investigated in female Wistar rats given single doses 10, 50 or 100 mg/kg by gastric tube. Renal lesions developed within 3 days, the effect being dose-dependent. Histologically, there evidence necrosis epithelium renal tubules, and functionally, were rises plasma creatinine urea together with increases urinary glucose, protein, N-acetyl-β-glucosaminidase, gammaglutamyl transferase malate dehydrogenase. Taking AA as an example, aim present study to consider suitability this model, based on a combination histology laboratory investigations, short-term test for detection agents.
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