Synthesis of 2,5-disubstituted benzimidazoles, 1,3,4-thiadiazoles and 3,5-diiodosalicylanilides as structural congeners of rafoxanide and closantel

摘要: The synthesis of a series 2,5-disubstituted benzimidazoles (8-10, 13), substituted 3,5-diodosalicylanilides (6, 7, 11, 12, 16-29), 2-(4-substituted phenyl)-4-aroylamino-1,3,4-thiadiazoles (33-38) and benzoxazines (14, 30, 31) has been carried out as the structural congeners rafoxanide closantel. All compounds have tested for their anthelmintic activity against Ancylostoma ceylanicum, Nippostrongylus brasiliensis, Hymenolepis nana Cysticecus fasciolaris in rodents. Compounds 8, 22 23 exhibited 90-100% elimination hookworms A. ceylanicum tapeworms H. from hamsters rats, respectively, at an oral dose 50-250 mg/kg body mass.