HPV DNA Typing of Adult-Onset Respiratory Papillomatosis

摘要: Respiratory papillomatosis is a recalcitrant, human pap-illomavirus-induced disorder of the upper airways. Using in situ hybridization and biotinylated deoxyribonucleic acid (DNA) probes, type papillomavirus (HPV) nine adults was determined both at presentation during subsequent recurrences. Fifty-three biopsies obtained from seven men two women over 10-year period were examined for HPV 6, 11, 16 18. All patients had either 6 or 11. One dual infection found. Despite intensive therapy with lasers without alpha interferon, no elimination change viral occurred. identical histologies, amount DNA present given patient's papillomata varied markedly. The results suggest that adult-onset respiratory due to and/or its recurrent nature, despite therapy, persistence reservoir.