Experimental Studies on the Pathogenesis of Damage in the Heart

摘要: Radiation-induced heart disease has been observed in a significant number of patients following mediastinal radiotherapy Hodgkin’s or postoperative breast cancer. Following higher radiation doses and especially treatments delivering particularly high dose to the anterior pericardium, reversible exudative pericarditis can occur within first 2–3 years (Pierce et al. 1969; Byhardt 1975; Gottdiener 1983; Greenwood 1974; Applefeld Wiernik 1983). A compilation clinical data shown that incidence rises sharply with pericardium (Schultz-Hector 1991a). Since modern techniques achieve more homogeneous distribution, become rare event is no longer major concern (Carmel Kaplan 1976; Watchie 1987; Morgan 1985). With increasing survival times, Hodgkin patients, late effects on myocardial function have observed. In left ventricular ejection fractions were reduced at 5–25 postirradiation (Morgan 1985; Burns Savage 1990; Gomez Although these asymptomatic, one assume cardiac reserve capacity, i.e., ability compensate for stress other origin, patients. We therefore developed an animal model study pathogenesis radiation-induced dysfunction.