Endogenous ouabain and aldosterone are coelevated in the circulation of patients with essential hypertension.

摘要: OBJECTIVE In the setting of normal sodium (Na) intake, many patients with hypertension have inappropriately elevated plasma aldosterone (Aldo) levels and may be at increased risk for tissue damage. Moreover, other adrenocortical steroids, including endogenous ouabain can stimulate As is often in chronically Na-loaded states, a vasoconstrictor, raises blood pressure (BP), also promotes fibrosis, we investigated extent to which Aldo were coelevated among naive hypertensive (NHP). We impact an acute salt load on these BP, renal function. METHODS NHP (590) grouped tertiles based their baseline (mean ± SEM first 7.59 ± 0.18, versus third 24.15 ± 0.31 ng/dl). Baseline renin activity (2.4 ± 0.1 1.2 ± 0.1 ng/ml per h, P < 0.001), (268 ± 14.9 pmol/l 239.0 ± 13.6 pmol, P < 0.01) DBP (91.9 ± 0.76 89.6 ± 0.71 mmHg, P = 0.017) higher tertile, respectively. RESULTS Acute Na loading showed that BP tertile was especially salt-sensitive (slope pressure-natriuresis relationship 0.015 ± 0.002 0.003 ± 0.001 μEq/mmHg min, P = 0.00024 after adjustment sex, BMI, age). Regression analyses linearly related (β = 0.181, P = 0.0003). CONCLUSION Among essential hypertension, circulating are typically salt-sensitive. conditions where elevated, both contribute adverse cardiovascular outcomes.