Abnormally sustained aldosterone secretion during salt loading in patients with various forms of benign hypertension; relation to plasma renin activity

摘要: A B S T R C Among 25 patients with benign, essential hypertension, and an equal number other benign forms of without serious cardiac, renal, or cerebrovascular impairment, 41 cases failed to reduce aldosterone excretion rates into the normal range (less than 5 Ag/day) on a daily intake 300 mEq sodium. The hypertensive excreted slightly less fraction labeled as acidhydrolyzable conjugate. Secretion were significantly higher in normotensive controls taking high-sodium intake. On 10 sodium intake, increase secretion could be correlated plasma renin activity (PRA). least PRA had subnormal excretion, while unusually large rises accompanied high PRA, especially increased angiotensinogen induced by oral contraceptives. persistence inappropriately most during loading related that found under comparable conditions. In hypertensives, whose was unresponsive depletion, there no significant correlation between output, known stimulus production detected. Five obvious hyperaldosteronism among 16 low-renin patients. cause nonsuppressible -low-renin remains determined.