Comparative efficacy and safety of bepridil and diltiazem in chronic stable angina pectoris refractory to diltiazem
作者： Bramah N. Singh
DOI: 10.1016/0002-9149(91)90824-5
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摘要: Abstract The efficacy and safety of bepridil hydrochloride (200 to 400 mg/day) were evaluated in patients with chronic stable angina refractory maximal tolerated doses diltiazem (median 360 a randomized, multicenter, double-blind, parallel study. Baseline data obtained during 2-week period, after which 86 randomized (n = 46) or 40). Angina frequency, nitroglycerin consumption ischemic manifestations induced by exercise treadmill testing over 8 weeks. Bepridil significantly (p
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sci-hub.se 参考文章(24)
Erne P, Müller Fb, Bolli P, Bühler Fr, Hulthén Ul, Kiowski W, Mechanisms of action and clinical use of calcium antagonists in hypertension. Circulation. ,vol. 80, pp. 136- 144 ,(1989)
William Shapiro, Robert DiBianco, Udho Thadani, Comparative efficacy of 200, 300 and 400 mg of bepridil for chronic stable angina pectoris The American Journal of Cardiology. ,vol. 55, pp. C36- C42 ,(1985) , 10.1016/0002-9149(85)90804-5
Randall M. Zusman, Donna M. Christensen, David J. Kanarek, Marla C. Kiess, Charles A. Boucher, Evaluation of bepridil for the treatment of angina pectoris: Evidence for preservation of left ventricular function The American Journal of Cardiology. ,vol. 55, pp. C30- C35 ,(1985) , 10.1016/0002-9149(85)90803-3
James A. Hill, John T. O'Brien, Elizabeth Scott, C.Richard Conti, Carl J. Pepine, Effects of Bepridil on exercise tolerance in chronic stable angina: A double-blind, randomized, placebo-controlled, crossover trial American Journal of Cardiology. ,vol. 53, pp. 679- 683 ,(1984) , 10.1016/0002-9149(84)90385-0
Bernard R. Chaitman, Pierre Wagniart, Andre Pasternac, Genevieve Brevers, Jean-Marie Scholl, Jules Lam, Margot Methe, Ronald J. Ferguson, Martial G. Bourassa, Improved exercise tolerance after propranolol, diltiazem or nifedipine in angina pectoris: Comparison at 1, 3 and 8 hours and correlation with plasma drug concentration The American Journal of Cardiology. ,vol. 53, pp. 1- 9 ,(1984) , 10.1016/0002-9149(84)90674-X
DiBianco Robert, Alpert Joseph, Richard J. Katz, Spann James, Chesler Elliot, Donald P. Ferri, Louis J. Larca, Costello Rebecca Bortz, Joel M. Gore, Myron J. Eisenman, Bepridil for chronic stable angina pectoris: Results of a prospective multicenter, placebo-controlled, dose-ranging study in 77 patients The American Journal of Cardiology. ,vol. 53, pp. 35- 41 ,(1984) , 10.1016/0002-9149(84)90680-5
Kenneth A. Narahara, William Shapiro, Irving Weliky, Janet Park, Evaluation of bepridil, a new antianginal agent: Clinical and hemodynamic alterations during the treatment of stable angina pectoris The American Journal of Cardiology. ,vol. 53, pp. 29- 34 ,(1984) , 10.1016/0002-9149(84)90679-9
John Somberg, Vilma Torres, David Flowers, Dennis Miura, Brenda Butler, Sheryl Gottlieb, Prolongation of QT interval and antiarrhythmic action of bepridil American Heart Journal. ,vol. 109, pp. 19- 27 ,(1985) , 10.1016/0002-8703(85)90410-7
Bramah N. Singh, Harvey S. Hecht, Koonlawee Nademanee, Christopher Y.C. Chew, Electrophysiologic and hemodynamic effects of slow-channel blocking drugs Progress in Cardiovascular Diseases. ,vol. 25, pp. 103- 132 ,(1982) , 10.1016/0033-0620(82)90023-8
Lon G. Sherman, Chang-Seng Liang, Nifedipine in chronic stable angina: a double-blind placebo-controlled crossover trial. American Journal of Cardiology. ,vol. 51, pp. 706- 711 ,(1983) , 10.1016/S0002-9149(83)80119-2