Subchondral bone changes in hand and knee osteoarthritis detected by radiography

摘要: Abstract Objective: To describe the changes in subchondral bone that occur with onset and progression of osteoarthritis (OA) from macroradiographic assessment patient's hand knee joints. Design: The high magnification spatial resolution macroradiography permits detailed anatomical to be detected OA Data on cortical cancellous bone, recorded both cross-sectional longitudinal studies OA, are described discussed reference recent findings altered biomechanical properties bone. Results: In joints, plate subjacent horizontal trabeculae increase thickness early, prior joint space narrowing (JSN). With progression, sclerosis increased 60% hands did not change until JSN Conclusions: weaker than normal within thickened joints leads, advanced deformation articular surfaces absorption local stresses producing an effect similar stress-shielding. This effect, it is suggested, results subarticular osteoporosis.