Spinal Ischemia-Induced Paraplegia

作者: Osamu Kakinohana , Tony L. Yaksh , Joho Tokumine , Martin Marsala

DOI: 10.1007/978-1-59259-298-2_14

关键词:

摘要: Transient spinal cord ischemia and subsequent loss of neurological function (spastic or flaccid paraplegia) represents a serious complication associated with transient aortic cross-clamp (as used in repair aneurysm). In clinical studies, it has been demonstrated that the incidence paraparesis developed spastic paraplegia range between 12% 40% patients extensive thoracoabdominal aneurysm (1,2). Although spontaneous recovery was noted fraction patients, who displayed motor dysfunction early after reflow, majority cases this deficit is irreversible. accordance these data, experimental studies using monkey, cat, dog, rabbit, rat models show occlusion will lead to comparable including weakness permanent (2–8).

参考文章(102)
CG Craig, V Tropepe, CM Morshead, BA Reynolds, S Weiss, D van der Kooy, In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain The Journal of Neuroscience. ,vol. 16, pp. 2649- 2658 ,(1996) , 10.1523/JNEUROSCI.16-08-02649.1996
Vijayabalan Balasingam, Voon Wee Yong, Attenuation of Astroglial Reactivity by Interleukin-10 The Journal of Neuroscience. ,vol. 16, pp. 2945- 2955 ,(1996) , 10.1523/JNEUROSCI.16-09-02945.1996
M. Deckert-Schlüter, N. Kaefer, H. Hof, O. D. Wiestler, D. Schlüter, Expression pattern and cellular origin of cytokines in the normal and Toxoplasma gondii-infected murine brain. American Journal of Pathology. ,vol. 150, pp. 1021- 1035 ,(1997)
P W Andrews, N C Dracopoli, J Føgh, D Simon, C Carlin, I Damjanov, G S Banting, Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro. Laboratory Investigation. ,vol. 50, pp. 147- 162 ,(1984)
John W. McDonald, Xiao-Zhong Liu, Yun Qu, Su Liu, Shannon K. Mickey, Dorothy Turetsky, David I. Gottlieb, Dennis W. Choi, Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nature Medicine. ,vol. 5, pp. 1410- 1412 ,(1999) , 10.1038/70986
Stephen J. A. Davies, Michael T. Fitch, Stacey P. Memberg, Alison K. Hall, Geoffrey Raisman, Jerry Silver, Regeneration of adult axons in white matter tracts of the central nervous system Nature. ,vol. 390, pp. 680- 683 ,(1997) , 10.1038/37776
Rosemary A. Fricker, Melissa K. Carpenter, Christian Winkler, Corinne Greco, Monte A. Gates, Anders Björklund, Site-Specific Migration and Neuronal Differentiation of Human Neural Progenitor Cells after Transplantation in the Adult Rat Brain The Journal of Neuroscience. ,vol. 19, pp. 5990- 6005 ,(1999) , 10.1523/JNEUROSCI.19-14-05990.1999
JS Rudge, J Silver, Inhibition of neurite outgrowth on astroglial scars in vitro The Journal of Neuroscience. ,vol. 10, pp. 3594- 3603 ,(1990) , 10.1523/JNEUROSCI.10-11-03594.1990