Inhibiting RORγt/Th17 axis for autoimmune disorders
作者： Fujio Isono , Saori Fujita-Sato , Shuichiro Ito
DOI: 10.1016/J.DRUDIS.2014.04.012
关键词:
摘要: … inhibitors for RORγt that bind to its ligand-binding domain (LBD) and suppress Th17 function in vitro and in vivo [8]. In this review we focus on RORγt … of RORγt inhibitors and discuss the …
elsevier.com
sci-hub.se 参考文章(47)
Jun R. Huh, Erika E. Englund, Hang Wang, Ruili Huang, Pengxiang Huang, Fraydoon Rastinejad, James Inglese, Christopher P. Austin, Ronald L. Johnson, Wenwei Huang, Dan R. Littman, Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors ACS Medicinal Chemistry Letters. ,vol. 4, pp. 79- 84 ,(2013) , 10.1021/ML300286H
Jun R. Huh, Dan R. Littman, Small molecule inhibitors of RORγt: targeting Th17 cells and other applications. European Journal of Immunology. ,vol. 42, pp. 2232- 2237 ,(2012) , 10.1002/EJI.201242740
Gerard Eberl, Dan R. Littman, The role of the nuclear hormone receptor RORgammat in the development of lymph nodes and Peyer's patches. Immunological Reviews. ,vol. 195, pp. 81- 90 ,(2003) , 10.1034/J.1600-065X.2003.00074.X
Tao Xu, Xiaohu Wang, Bo Zhong, Roza I. Nurieva, Sheng Ding, Chen Dong, Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORγt Protein * Journal of Biological Chemistry. ,vol. 286, pp. 22707- 22710 ,(2011) , 10.1074/JBC.C111.250407
Richard S Blumberg, Bonnie Dittel, David Hafler, Matthias von Herrath, Frank O Nestle, Unraveling the autoimmune translational research process layer by layer Nature Medicine. ,vol. 18, pp. 35- 41 ,(2012) , 10.1038/NM.2632
Jun R. Huh, Monica W. L. Leung, Pengxiang Huang, Daniel A. Ryan, Michael R. Krout, Raghu R. V. Malapaka, Jonathan Chow, Nicolas Manel, Maria Ciofani, Sangwon V. Kim, Adolfo Cuesta, Fabio R. Santori, Juan J. Lafaille, H. Eric Xu, David Y. Gin, Fraydoon Rastinejad, Dan R. Littman, Digoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORγt activity Nature. ,vol. 472, pp. 486- 490 ,(2011) , 10.1038/NATURE09978
Chenhui Wang, Ling Wu, Katarzyna Bulek, Bradley N Martin, Jarod A Zepp, Zizhen Kang, Caini Liu, Tomasz Herjan, Saurav Misra, Julie A Carman, Ji Gao, Ashok Dongre, Shujie Han, Kevin D Bunting, Jennifer S Ko, Hui Xiao, Vijay K Kuchroo, Wenjun Ouyang, Xiaoxia Li, None, The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90 Nature Immunology. ,vol. 14, pp. 72- 81 ,(2013) , 10.1038/NI.2479
Gillian M Bell, Gary Reynolds, John D Isaacs, None, Biologic therapies in non-rheumatic diseases: lessons for rheumatologists? Nature Reviews Rheumatology. ,vol. 7, pp. 507- 516 ,(2011) , 10.1038/NRRHEUM.2011.106
Sascha Rutz, Céline Eidenschenk, Wenjun Ouyang, IL-22, not simply a Th17 cytokine Immunological Reviews. ,vol. 252, pp. 116- 132 ,(2013) , 10.1111/IMR.12027
Saori Fujita-Sato, Shuichiro Ito, Takashi Isobe, Takao Ohyama, Kenji Wakabayashi, Kaoru Morishita, Osamu Ando, Fujio Isono, Structural Basis of Digoxin That Antagonizes RORγt Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production Journal of Biological Chemistry. ,vol. 286, pp. 31409- 31417 ,(2011) , 10.1074/JBC.M111.254003