Unraveling the autoimmune translational research process layer by layer

作者: Richard S Blumberg , Bonnie Dittel , David Hafler , Matthias von Herrath , Frank O Nestle

DOI: 10.1038/NM.2632

关键词:

摘要: Autoimmune diseases have a complex etiology and despite great progress having been made in our comprehension of these disorders, there has limited success the development approved medications based on insights. Development drugs strategies for application translational research medicine are hampered by an inadequate molecular definition human autoimmune phenotype organizational models that necessary to clarify this definition.

参考文章(69)
E. Zerhouni, Medicine. The NIH Roadmap. Science. ,vol. 302, pp. 63- 72 ,(2003) , 10.1126/SCIENCE.1091867
Holden T Maecker, J Philip McCoy Jr, None, A model for harmonizing flow cytometry in clinical trials Nature Immunology. ,vol. 11, pp. 975- 978 ,(2010) , 10.1038/NI1110-975
D. Korn, SCIENCE POLICY: The NIH Budget in the "Postdoubling" Era Science. ,vol. 296, pp. 1401- 1402 ,(2002) , 10.1126/SCIENCE.1072486
Ismail Kola, John Landis, Can the pharmaceutical industry reduce attrition rates? Nature Reviews Drug Discovery. ,vol. 3, pp. 711- 716 ,(2004) , 10.1038/NRD1470
Robert B. Nussenblatt, Bibiana Bielekova, Richard Childs, Alan Krensky, Warren Strober, Giorgio Trinchieri, , National Institutes of Health Center for Human Immunology Conference, September 2009. Annals of the New York Academy of Sciences. ,vol. 1200, ,(2010) , 10.1111/J.1749-6632.2010.05682.X
Jean-François Bach, The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases The New England Journal of Medicine. ,vol. 347, pp. 911- 920 ,(2002) , 10.1056/NEJMRA020100
Janice Reichert, Monoclonal antibodies as innovative therapeutics. Current Pharmaceutical Biotechnology. ,vol. 9, pp. 423- 430 ,(2008) , 10.2174/138920108786786358
Andrew C. Chan, Paul J. Carter, Therapeutic antibodies for autoimmunity and inflammation Nature Reviews Immunology. ,vol. 10, pp. 301- 316 ,(2010) , 10.1038/NRI2761
Matthias von Herrath, Andrew Chan, How can we improve the translational landscape for a faster cure of type 1 diabetes Journal of Clinical Investigation. ,vol. 119, pp. 1061- 1065 ,(2009) , 10.1172/JCI37593
Cara C. Tigue, Karen A. Fitzner, Motasem Alkhatib, Eric Schmid, Charles L. Bennett, The value of innovation : the economics of targeted drugs for cancer Targeted Oncology. ,vol. 2, pp. 113- 119 ,(2007) , 10.1007/S11523-007-0043-8