Cerebral glucose metabolism in adults with attention deficit hyperactivity disorder after chronic stimulant treatment

摘要: Objective: The authors examined the effects of chronic stimulant treatment on cerebral glucose metabolism in adults diagnosed with attention deficit hyperactivity disorder (ADHD), who were studied by means ofpositron emission tomography (PET) [18F]fluorodeoxyglucose as tracer. Method: Each subject received two PET scans, first before drug and second after daily oral doses, individually titrated for clinical effect, ofeither methylphenidate (N=1 9) or d-amphetamine 8) a minimum of6 weeks. subjects completed behavioral self-report measures at end ofthe medication period. Results: Neither changed global, whole-brain, metabolism, although both drugs increased systolic blood pressure. Metabolism only 60 brain regions sampled was methylphenidate, while exhibited no effect regional metabolism. Both associated significant improvement behavior, evidenced improved ratings restlessness ability to maintain attention. Conclusions: While present study does not demonstrate any robust metabolic treatment, data strongly indicate that are effective agents ofadults ADHD. (Am J Psychiatry 1 994; 151:658-664)