The Pharmacotherapy of Neuropsychiatric Symptoms of Dementia

作者: Tomislav Majic , Jan-Paul Pluta , Thomas Mell , Marion C. Aichberger , Yvonne Treusch

DOI: 10.3238/ARZTEBL.2010.0320

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摘要: SUMMARY Background: The neuropsychiatric symptoms of dementia, including aggressiveness, agitation, depres sion, and apathy are often treated with psychotropic drugs a frequent reason for hospitalization, placing an economic burden on the health care system. International guidelines recommend syndrome-specific pharmacotherapy. We studied question whether drug-prescribing practices are, in fact, syndromespecific. Methods: In cross-sectional study 18 homes elderly Berlin, we used scales to determine prevalence apathy, depression, aggressiveness quantity prescribed, defined daily dosages (DDD), among 304 demented inhabitants. diagnosis dementia was ascertained by chart review confirmed administration mini mental status test.

参考文章(18)
S. Weyerer, M. Schäufele, I. Hendlmeier, Besondere und traditionelle stationäre Betreuung demenzkranker Menschen im Vergleich Zeitschrift Fur Gerontologie Und Geriatrie. ,vol. 38, pp. 85- 94 ,(2005) , 10.1007/S00391-005-0293-Y
Mark Snowden, Kersten Sato, Peter Roy-Byrne, Assessment and treatment of nursing home residents with depression or behavioral symptoms associated with dementia: a review of the literature. Journal of the American Geriatrics Society. ,vol. 51, pp. 1305- 1317 ,(2003) , 10.1046/J.1532-5415.2003.51417.X
Ann L. Gruber-Baldini, Malaz Boustani, Philip D. Sloane, Sheryl Zimmerman, Behavioral Symptoms in Residential Care/Assisted Living Facilities: Prevalence, Risk Factors, and Medication Management Journal of the American Geriatrics Society. ,vol. 52, pp. 1610- 1617 ,(2004) , 10.1111/J.1532-5415.2004.52451.X
Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh, “Mini-mental state” Journal of Psychiatric Research. ,vol. 12, pp. 189- 198 ,(1975) , 10.1016/0022-3956(75)90026-6
Patricia A. Boyle, Paul F. Malloy, Treating apathy in Alzheimer's disease. Dementia and Geriatric Cognitive Disorders. ,vol. 17, pp. 91- 99 ,(2004) , 10.1159/000074280
Janet Keene, Tony Hope, Christopher G. Fairburn, Robin Jacoby, Kathy Gedling, Christopher J. G. Ware, Natural history of aggressive behaviour in dementia. International Journal of Geriatric Psychiatry. ,vol. 14, pp. 541- 548 ,(1999) , 10.1002/(SICI)1099-1166(199907)14:7<541::AID-GPS961>3.0.CO;2-P
Robert S. Marin, Ruth C. Biedrzycki, Sekip Firinciogullari, Reliability and validity of the apathy evaluation scale Psychiatry Research. ,vol. 38, pp. 143- 162 ,(1991) , 10.1016/0165-1781(91)90040-V
Gordon K. Wilcock, Clive G. Ballard, James A. Cooper, Henrik Loft, Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer's disease: a pooled analysis of 3 studies. The Journal of Clinical Psychiatry. ,vol. 69, pp. 341- 348 ,(2008) , 10.4088/JCP.V69N0302
I. Testad, A. M. Aasland, D. Aarsland, Prevalence and correlates of disruptive behavior in patients in Norwegian nursing homes. International Journal of Geriatric Psychiatry. ,vol. 22, pp. 916- 921 ,(2007) , 10.1002/GPS.1766