Epigenetic gene regulation in cancer.

摘要: The observation that cancer cells suffer profound alterations in the DNA methylation profile, with functional consequences activity of key genes, together recognition epigenetic might be as important genetic defects origin cancers has started a new era research. In few years, discoveries have abruptly changed our vision determinants cancer. Breakthroughs epigenetics field include finding tumor-type specificity genes deregulation at both and histone modifications, interconnection between different marks, identification mechanisms targeting alterations, including participation Polycomb group (PcG) proteins, or involvement small RNAs, which regulate hundreds target genes. All these findings multiple implications: first, they shed light on mechanistic insights by complement development progression cancer; second, appear to play prominent role initiation addition, because changes are reversible, enzymes involved their maintenance stand targets for variety compounds therapy.