Possible therapeutic effects of vindoline on testicular and epididymal function in diabetes-induced oxidative stress male Wistar rats.

摘要: Abstract Objective The study evaluated the effects of vindoline on testicular and epididymal oxidative stress in diabetes-induced male Wistar rats. Methods Forty-eight (48), 6-week old rats weighing between 190-230g were divided into 6 groups (n = 8) used for this study. Group 1 was normal control, group 2 comprised non-diabetic treated with vindoline, 3 glibenclamide-the standard drug treatment diabetes. 4 diabetic 5 glibenclamide. Diabetes induced 4, by subjecting them to 10% fructose water over a period weeks, followed administration single intraperitoneal injection 40 mg/kg b.w streptozotocin (STZ). Testicular lipid peroxidation levels, antioxidant enzymes, scavenging activity total capacity measured. Results Diabetes-induced demonstrated chronic hyperglycaemia, reduced oxygen radical absorption both tissues. Short-term weeks significantly fasting blood glucose minimise stress, increased catalase SOD increase capacity. Conclusion Treatment showed protective against tissues rats, hence can be considered potential agent management sexual dysfunction.