Genomic Analysis of Nasopharyngeal Carcinoma Reveals TME-Based Subtypes

摘要: Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated cancer characterized by a poor prognosis and high level of lymphocyte infiltrate. Genetic hallmarks NPC are not completely known but include deletion the p16 (CDKN2A) locus mutations in NF-κB pathway components, with relatively low total mutational load. To better understand genetic landscape, integrated genomic analysis was performed using large clinical cohort treatment-naive tumor specimens. This generally concordant previous studies; however, three subtypes were identified differences immune cell gene expression, prognosis, morphology, characteristics. A expression signature proliferation poorly prognostic either higher mutation load or specific EBV patterns subtype-specific manner. Finally, levels stromal tumor-infiltrating lymphocytes good lower WNT TGFβ activation signature.Implications: study represents first mutation, copy number, data suggests how genetics infection influence microenvironment this disease. These insights should be considered for guiding immunotherapy treatment strategies Mol Cancer Res; 15(12); 1722-32. ©2017 AACR.