CAF-1 and the inheritance of chromatin states: at the crossroads of DNA replication and repair.

作者: G. Almouzni , P. Ridgway

DOI: 10.1242/JCS.113.15.2647

关键词:

摘要: Chromatin is no longer considered to be a static structural framework for packaging DNA within the nucleus but instead believed an interactive component of metabolism. The ordered assembly chromatin produces nucleoprotein template capable epigenetically regulating expression and maintenance genome. Factors have been isolated from cell extracts that stimulate early steps in vitro. function one such factor, chromatin-assembly factor 1 (CAF-1), might extend beyond simply facilitating progression through individual reaction its active participation marking system. This system could exploited at crossroads replication repair monitor genome integrity define particular epigenetic states.

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