In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue
作者： Miles E. Matsen , Joshua P. Thaler , Brent E. Wisse , Stephan J. Guyenet , Thomas H. Meek
DOI: 10.1152/AJPENDO.00488.2012
关键词:
摘要: Recent advances in human brown adipose tissue (BAT) imaging technology have renewed interest the identification of BAT activators for treatment obesity and diabetes. In uncontrolled diabe...
sci-hub.se 参考文章(58)
C. M. Arbeeny, D. S. Meyers, D. E. Hillyer, K. E. Bergquist, Metabolic alterations associated with the antidiabetic effect of beta 3-adrenergic receptor agonists in obese mice. American Journal of Physiology-endocrinology and Metabolism. ,vol. 268, ,(1995) , 10.1152/AJPENDO.1995.268.4.E678
J.P. Giacobino, C.M. Fraser, P. Muzzin, J.P. Revelli, F. Kuhne, J.D. Gocayne, W.R. McCombie, J.C. Venter, An adipose tissue-specific beta-adrenergic receptor. Molecular cloning and down-regulation in obesity. Journal of Biological Chemistry. ,vol. 266, pp. 24053- 24058 ,(1991) , 10.1016/S0021-9258(18)54391-X
J. A. McLean, G. Tobin, Animal and Human Calorimetry ,(1988)
R Burcelin, J Kande, D Ricquier, J Girard, Changes in uncoupling protein and GLUT4 glucose transporter expressions in interscapular brown adipose tissue of diabetic rats: relative roles of hyperglycaemia and hypoinsulinaemia Biochemical Journal. ,vol. 291, pp. 109- 113 ,(1993) , 10.1042/BJ2910109
Aaron M. Cypess, Sanaz Lehman, Gethin Williams, Ilan Tal, Dean Rodman, Allison B. Goldfine, Frank C. Kuo, Edwin L. Palmer, Yu-Hua Tseng, Alessandro Doria, Gerald M. Kolodny, C. Ronald Kahn, Identification and Importance of Brown Adipose Tissue in Adult Humans The New England Journal of Medicine. ,vol. 360, pp. 1509- 1517 ,(2009) , 10.1056/NEJMOA0810780
Celia A Williams, Mei-Fen Shih, Peter V Taberner, Sustained improvement in glucose homeostasis in lean and obese mice following chronic administration of the β3 agonist SR 58611A British Journal of Pharmacology. ,vol. 128, pp. 1586- 1592 ,(1999) , 10.1038/SJ.BJP.0702946
KEIJI YOSHIOKA, TOSHIHIDE YOSHIDA, YASUO WAKABAYASHI, HITOSHI NISHIOKA, MOTOHARU KONDO, The role of insulin in norepinephrine turnover and thermogenesis in brown adipose tissue after acute cold-exposure. Endocrinologia Japonica. ,vol. 36, pp. 491- 499 ,(1989) , 10.1507/ENDOCRJ1954.36.491
S. P. Weinstein, E. O'Boyle, R. S. Haber, Thyroid Hormone Increases Basal and Insulin-Stimulated Glucose Transport in Skeletal Muscle: The Role of GLUT4 Glucose Transporter Expression Diabetes. ,vol. 43, pp. 1185- 1189 ,(1994) , 10.2337/DIAB.43.10.1185
Jonathan P. German, Joshua P. Thaler, Brent E. Wisse, Shinsuke Oh-I, David A. Sarruf, Miles E. Matsen, Jonathan D. Fischer, Gerald J. Taborsky, Michael W. Schwartz, Gregory J. Morton, Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia Endocrinology. ,vol. 152, pp. 394- 404 ,(2011) , 10.1210/EN.2010-0890
Nancy J. Rothwell, Michael J. Stock, A role for brown adipose tissue in diet-induced thermogenesis Obesity Research. ,vol. 5, pp. 650- 656 ,(1997) , 10.1002/J.1550-8528.1997.TB00591.X