The role of insulin in norepinephrine turnover and thermogenesis in brown adipose tissue after acute cold-exposure.
作者： KEIJI YOSHIOKA , TOSHIHIDE YOSHIDA , YASUO WAKABAYASHI , HITOSHI NISHIOKA , MOTOHARU KONDO
DOI: 10.1507/ENDOCRJ1954.36.491
关键词:
摘要: The role of insulin in norepinephrine turnover (NE) and thermogenesis brown adipose tissue (BAT) after acute cold-exposure was studied using streptozocin (STZ)-induced diabetic rats. NE estimated by the synthesis inhibition technique with alpha-methyl-p-tyrosine. BAT measuring mitochondrial guanosine-5'-diphosphate (GDP), cytochrome oxidase activity oxygen consumption at an ambient temperature 22 degrees C during a six-hour 4 C. In insulin-deficient rats, turnover, GDP binding, were significantly reduced, compared those control Treatment STZ-induced rats prevented decrease thermogenesis. Acute increased thermogenic response to cold-exposure, however, did not occur These results suggest that is essential potentiating but required for cold-induced
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