BETAGLYCAN POLYPEPTIDES HAVING TGF-β BINDING ACTIVITY

作者: Erkki Ruoslahti , Daikichi Fukushima , Ralf Butzow

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摘要: This invention provides polypeptides that bind to TGF-β and have an amino acid sequence of a portion mammalian betaglycan. These enhance binding type II receptor enchance the suppression cell growth by TGF-β. also isolated nucleic molecules encoding these polypeptides. methods detecting isolating pharmaceutical compositions having peptides therapeutic uses them. decoy betaglycan polypeptides, anti-betaglycan-binding-site antibodies anti-idiotypic against anti-betaglycan. It compositions.

参考文章(3)
Joan Massagué, Janet Andres, Liliana Attisano, Sela Cheifetz, Fernando López-Casillas, Masahiko Ohtsuki, Jeffrey L. Wrana, TGF‐β receptors Molecular Reproduction and Development. ,vol. 32, pp. 99- 104 ,(1992) , 10.1002/MRD.1080320204
D Fukushima, R Bützow, A Hildebrand, E Ruoslahti, Localization of transforming growth factor beta binding site in betaglycan. Comparison with small extracellular matrix proteoglycans. Journal of Biological Chemistry. ,vol. 268, pp. 22710- 22715 ,(1993) , 10.1016/S0021-9258(18)41585-2