Neurotransmitter modulation of calcium current in rat spinal cord neurons
作者： DW Sah
DOI: 10.1523/JNEUROSCI.10-01-00136.1990
关键词:
摘要: The modulation of Ca2+ currents by neurotransmitters was studied in freshly dissociated rat spinal cord neurons, using the whole-cell patch- clamp technique. GABA, baclofen, adenosine, ATP, serotonin, norepinephrine, somatostatin, and dynorphin A inhibited current through channels a substantial fraction cells, while substance P, vasoactive intestinal polypeptide, [D-ala2,d-leu5]- enkephalin, cholecystokinin-8 (sulfated), calcitonin gene-related peptide, angiotensin II, neurotensin, vasopressin, thyrotropin- releasing hormone had no effect. In case inhibition is mediated, at least part, GTP-binding protein. Suppression may represent mechanism presynaptic cord.
sci-hub.se 参考文章(48)
Michael T. Taussig, The Nervous System ,(1991)
JE Huettner, RW Baughman, Primary culture of identified neurons from the visual cortex of postnatal rats The Journal of Neuroscience. ,vol. 6, pp. 3044- 3060 ,(1986) , 10.1523/JNEUROSCI.06-10-03044.1986
E. Wanke, A. Ferroni, A. Malgaroli, A. Ambrosini, T. Pozzan, J. Meldolesi, Activation of a muscarinic receptor selectively inhibits a rapidly inactivated Ca2+ current in rat sympathetic neurons Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 4313- 4317 ,(1987) , 10.1073/PNAS.84.12.4313
S.V. Ramana Reddy, Tony L. Yaksh, Spinal noradrenergic terminal system mediates antinociception Brain Research. ,vol. 189, pp. 391- 401 ,(1980) , 10.1016/0006-8993(80)90099-2
R.A. Deisz, H.D. Lux, γ-Aminobutyric acid-induced depression of calcium currents of chick sensory neurons Neuroscience Letters. ,vol. 56, pp. 205- 210 ,(1985) , 10.1016/0304-3940(85)90130-2
Arvid Carlsson, Bengt Falck, Kjell Fuxe, Nils-Åre Hillarp, CELLULAR LOCALIZATION OF MONOAMINES IN THE SPINAL CORD. Acta Physiologica Scandinavica. ,vol. 60, pp. 112- 119 ,(1964) , 10.1111/J.1748-1716.1964.TB02874.X
R L MacDonald, J H Skerritt, M A Werz, Adenosine agonists reduce voltage-dependent calcium conductance of mouse sensory neurones in cell culture. The Journal of Physiology. ,vol. 370, pp. 75- 90 ,(1986) , 10.1113/JPHYSIOL.1986.SP015923
Richard Gray, Daniel Johnston, Noradrenaline and β-adrenoceptor agonists increase activity of voltage-dependent calcium channels in hippocampal neurons Nature. ,vol. 327, pp. 620- 622 ,(1987) , 10.1038/327620A0
Kathleen Dunlap, George G. Holz, Stanley G. Rane, G proteins as regulators of ion channel function. Trends in Neurosciences. ,vol. 10, pp. 241- 244 ,(1987) , 10.1016/0166-2236(87)90166-4
Huda Akil, David J. Mayer, Antagonism of stimulation-produced analgesia by p-CPA, a serotonin synthesis inhibitor Brain Research. ,vol. 44, pp. 692- 697 ,(1972) , 10.1016/0006-8993(72)90338-1