Antioxidant strategies and respiratory disease of the preterm newborn: an update.

摘要: Preterm newborns are challenged by an excessive oxidative burden, as a result of several perinatal stimuli, intrauterine infections, resuscitation, mechanical ventilation, and postnatal complications, in the presence immature antioxidant capacities. “Oxygen radical disease neonatology” comprises wide range conditions sharing common pathway pathogenesis includes bronchopulmonary dysplasia (BPD) other main complications prematurity. Antioxidant strategies may be beneficial prevention treatment stress- (OS-) related lung preterm newborn. Endotracheal supplementation or lung-targeted overexpression superoxide dismutase was proved to reduce damage models; however, newborn failed risk BPD, although long-term respiratory outcomes were improved. Also melatonin administration small cohorts suggested effects on OS. The possibility identify single nucleotide polymorphism affecting BPD help specific populations with particularly high OS-related diseases pose basis for individually targeted treatments. Finally, surfactant replacement lead local anti-inflammatory effects, thanks enzymatic nonenzymatic antioxidants naturally present animal surfactants.