Interleukin-6 polymorphism and bronchopulmonary dysplasia risk in very low-birthweight infants.

摘要: Background:  The aim of the present study was to evaluate role interleukin (IL)-6-634 polymorphism in neonatal disorders such as bronchopulmonary dysplasia (BPD) and periventricular leukomalacia (PVL) very low-birthweight (VLBW) infants. Methods:  This prospective cohort included 202 infants (gestational age at birth, 23–34 weeks; birthweight, 500–1499 g). Genotypic analysis (polymerase chain reaction–restriction fragment length polymorphism) performed with DNA extracted from whole-blood samples. Results:  Genotype distribution (66.8% CC, 28.2% CG, 5.0% GG) similar that adult Japanese population. BPD occurred 85 (42.1%) among VLBW infants. duration O2 therapy CG/GG genotypes significantly longer than CC genotype (CG/GG vs CC: 40.3 ± 52.2 days 28.4 32.6 days, P < 0.05), but prevalence not associated (CG/GG, 40.0%; 46.3%, P= 0.24). Infants were more likely have received postnatal corticosteroid for those 20.9% 11.1%, 0.05). PVL six (3.0%). There no significant difference IL-6-634 polymorphisms 3.0%; 3.0%, 0.65). Conclusions:  is oxygen suggests G allele an aggravating factor BPD. PVL.