Controlled Release of Bioactive Agents in Gene Therapy and Tissue Engineering

摘要: Even though the drugs are effective in treatment of some diseases, they may be inefficient or incapable solving problem other diseases. It is known that diseases have genetic causes and therefore search for a therapy these cases intense. The solutions involving either direct application gene its basic product, proteins, especially growth factors, oftencontemplated. Gene novel approach to treating based on modifying expression person’s genes toward therapeutic goal. While proteins offer great opportunity many their administration require critical consideration structure conditions. When conventional methods drug adopted results not successful. Genetic material too labile unstable due fragile 3-D structures this makes medium long periods unprotected form impossible. For delivery vivo, additional problems overcome, including anatomical size constraints, protection from nonspecific interactions with body fluids, extracellular matrix nontarget cells.