Tissue and serum somatostatin-like immunoreactivity in lean and obese Zucker rats.

摘要: Tissue and serum somatostatin levels were measured in genetically lean obese Zucker rats. Immunoreactive content was decreased three central nervous system regions (hypothalamus, septum preoptic area thalamus) of rats but increased cerebral cortex. No differences observed antral or colonic animals had significantly elevated pancreatic levels. Portal vein somatostatin-like immunoreactivity contrast lower The widespread alterations tissue suggest either a diffuse abnormality physiology response to generalised feature the hyperinsulinaemic state.