Variability of human papillomavirus DNA testing in a longitudinal cohort of young women.

摘要: OBJECTIVE To determine the variability in human papillomavirus (HPV) DNA testing of cervix young women found positive for HPV by dot blot hybridization on routine examination. METHODS Young who were to be DNA-positive screening using an RNA-DNA method asked return repeat sampling, cytology, colposcopic examination, and biopsy if indicated. Those had no histologic evidence cervical dysplasia every 4 months cytology standardized polymerase chain reaction techniques. RESULTS The followed a mean 27.6 (range 13-40) with six visits four ten). One-third remained consistently or intermittently hybridization, almost 50% Women more likely than at both 1 year after 2 years follow-up (P < .05). However, rates persistent tests either similar follow-up. Forty percent subjects new different types original type appear during All five spontaneous regression cytologic abnormalities became DNA-negative methods. CONCLUSIONS Our data suggest that portion infected eliminate infection over relatively short period are low risk developing disease. Persistent negativity was also those undergoing regression. substantial proportion reaction. This finding suggests virus remains latent some individuals may undergo reactivation, defined sufficient replication allow detection means less sensitive