Multiple genes identified as targets for 20q13.12-13.33 gain contributing to unfavorable clinical outcomes in patients with hepatocellular carcinoma.
作者： Dong Wang , Zhong-Zheng Zhu , Hongmei Jiang , Jiayi Zhu , Wen-Ming Cong
DOI: 10.1007/S12072-015-9642-0
关键词:
摘要: Recurrent chromosome 20q gain is implicated in progressive cancer behaviors and has been associated with clinical outcomes multiple types of cancer; however, its prognostic significance hepatocellular carcinoma (HCC) the involved genes remain unclear. Array comparative genomic hybridization expression arrays were used to detect copy number alterations (CNAs) levels, respectively. The associations between CNAs analyzed on 66 patients, for which follow-up period was 2.6–73.3 months. One hundred seventeen tumors further investigated identify target potentially outcome-related CNAs. Regional or whole detected 24 (36.4 %) HCC cases. most recurrent gains 20q11.21–12, 20q12–13.12, 20q13.12–13.33 20q13.33. Of CNAs, significantly reduced extrohepatic metastasis-free overall survival, as well elevated postoperative AFP level, tumor vascular invasion advanced stage. Multivariate Cox analysis identified an independent marker metastasis (HR 3.73, 95 % CI 1.08–12.87) death 3.00, 1.26–7.13). A panel 19 overexpressed HCCs compared without. High (greater than median) 5 genes, DDX27, B4GALT5, RNF114, ZFP64 PFDN4, correlated invasion, high RNF114 also Gain at a death, ZFP64, PFDN4 are probable may be together unfavorable patients.
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