LINAC based stereotactic radiotherapy of uveal melanoma: 4 years clinical experience.

摘要: Abstract Purpose : To study local tumor control and radiogenic side effects after fractionated LINAC based stereotactic radiotherapy for selected uveal melanoma. Patients methods Between June 1997 March 2001, 90 patients suffering from melanoma were treated at a with 6 MV. The head was immobilized modified frame system (BrainLAB). For stabilization of the eye position light source integrated into mask in front healthy or diseased eye. A mini-video camera used on-line movement control. Tumors included either located unfavorably respect to macula optical disc ( 7 mm. Median volume 305±234 mm 3 (range 70–1430 ), mean height 5.4±2.3 2.7–15.9 mm). Total doses 70 (single dose 14 Gy @ 80% isodose) 60 12 applied five fractions within 10 days. first fractionation results total (TD) (2 Gy) 175 238 normal tissue, corresponding values second schedule are 135 180 Gy, respectively. Results After median follow-up 20 months 1–48 months) achieved 98% n =88). relative reductions 24, 27, 37% 12, 24 36 months. Three (3.3%) developed metastases. Secondary enucleation performed seven (7.7%). Long term retinopathy (25.5%), cataract (18.9%), optic neuropathy (20%), secondary neovascular glaucoma (8.8%). Conclusion Fractionated photon beam therapy conjunction dedicated is highly effective method treat considered be sufficient achieve good