The effect of porosity and mechanical property of a synthetic polymer scaffold on repair of osteochondral defects
作者： Risa Ikeda , Hiroyuki Fujioka , Issei Nagura , Takeshi Kokubu , Narikazu Toyokawa
DOI: 10.1007/S00264-008-0532-0
关键词:
摘要: We have made three types of poly (DL-lactide-co-glycolide) (PLG) scaffolds (porosity: scaffold I 80 ± 0.9%, II 85 0.8%, III 92 0.7%; compression module determined with 10% strain: 0.26 MPa, 0.091 0.0047 MPa). Osteochondral defects in the femoral condyle rabbits were treated these and possibilities cartilage repair investigated histologically. At post-operative weeks 6 12, histological scores groups significantly higher than score group I. Scaffolds III, which porosity I, allow better migration bone marrow cells replacement This study suggests that allowing to migrate is important repairing osteochondral defects.
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