Current Concepts and Challenges in Osteochondral Tissue Engineering and Regenerative Medicine.

摘要: In the past few years, great progress has been made to validate tissue engineering strategies in preclinical studies and clinical trials on regeneration of osteochondral defects. studies, one dominant comprises development biomimetic/bioactive scaffolds, which are used alone or incorporated with growth factors and/or stem cells. Many new trends emerging for modulation cell fate toward osteogenic chondrogenic differentiations, but bone/cartilage interface physical stimulus have showing promise. Besides matrix-associated autologous chondrocyte implantation (MACI) procedure, (MASI) layered scaffolds acellular cellular strategy also applied clinic. This review outlines progresses at levels, identifies challenges engineering. Future perspectives provided, e.g., applications extrac...