Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone.

摘要: An understanding of the regulators neurogenesis in normal and diseased brain is necessary order to recruit endogenously produced neural precursors for cell replacement neurodegenerative disorders such as Parkinson's disease. The location dopaminergic projections from midbrain neostriatum nucleus accumbens overlaps with most active region adult brain, subventricular zone anterior lateral ventricle. This suggests that dopamine may contribute regulation niche neurogenesis. Here, we show mice destruction neurons substantia nigra ventral tegmental area a 6-hydroxydopamine model disease reduced number proliferating ventricle by approximately 40%. effect on precursor proliferation correlated extent denervation neighboring neostriatum. identifies one few known endogenous implications potential use strategies