c-erbB3 and c-erbB4 expression is a feature of the endocrine responsive phenotype in clinical breast cancer.

摘要: We examined c-erbB3 and c-erbB4 mRNA expression in 47 primary breast cancer samples by simultaneous RT-PCR have investigated correlations between these parameters the of both ER EGFR protein as measured ICA with Ki67 immunostaining. A direct association was found marker status either (c-erbB3 P=0.0003; P=0.02) or (c-erbB-3 P=0.002; P=0.01). Inverse associations were seen membrane (c-erbB3: P=0.003; c-erbB4: P=0.003) (c-erbB4: P=0.009) status. These reinforced Spearman Rank Correlation Tests. significant relationship level. Measurements levels tumour removed from a further 89 patients known response to endocrine therapy: (i) confirmed (ii) identified that whose positive tumours expressed high most likely benefit measures. non-significant trend recorded results clearly demonstrate increased appears be associated prognostically-favourable phenotype.