Cardiovascular Aspects in Laron Syndrome Patients

作者: Mickey Scheinowitz , Micha S. Feinberg , Michael Shechter , Zvi Laron , Rivka Kauli

DOI: 10.1007/978-3-642-11183-9_33

关键词:

摘要: The chapter describes the role of congenital insulin-like growth factor I (IGF-I) deficiency, such as in patients with Laron syndrome, on cardiac function, exercise capacity, endothelial and intimal thickening. Despite small dimensions, heart function is normal, capacity significantly reduced similar to that normal controls. Brachial artery diameter was smaller than controls but no differences measures. Intimal thickening common carotid internal arteries slightly higher LS compared data highlight risks for cardiovascular disease IGF-I deficiency.

参考文章(58)
Mary C Corretti, Todd J Anderson, Emelia J Benjamin, David Celermajer, Francois Charbonneau, Mark A Creager, John Deanfield, Helmut Drexler, Marie Gerhard-Herman, David Herrington, Patrick Vallance, Joseph Vita, Robert Vogel, Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force Journal of the American College of Cardiology. ,vol. 39, pp. 257- 265 ,(2002) , 10.1016/S0735-1097(01)01746-6
J. Szczepanska Kostro, J. Tolwinska, M. Urban, M. Gardziejczyk, B. Glowińska, Cardiac mass and function, carotid artery intima media thickness, homocysteine and lipoprotein levels in children and adolescents with growth hormone deficiency. Journal of Pediatric Endocrinology and Metabolism. ,vol. 17, pp. 1405- 1413 ,(2004) , 10.1515/JPEM.2004.17.10.1405
Roland W. McCallum, Christopher A. R. Sainsbury, Angela Spiers, Anna F. Dominiczak, John R. Petrie, Naveed Sattar, John M. C. Connell, Growth hormone replacement reduces C-reactive protein and large-artery stiffness but does not alter endothelial function in patients with adult growth hormone deficiency. Clinical Endocrinology. ,vol. 62, pp. 473- 479 ,(2005) , 10.1111/J.1365-2265.2005.02245.X
Zvi Laron, Shira Ginsberg, Pearl Lilos, Mira Arbiv, Nahum Vaisman, Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity). Clinical Endocrinology. ,vol. 65, pp. 114- 117 ,(2006) , 10.1111/J.1365-2265.2006.02558.X
M. Scheinowitz, G. Kessler-Icekson, S. Freimann, R. Zimmermann, W. Schaper, E. Golomb, N. Savion, M. Eldar, Short- and long-term swimming exercise training increases myocardial insulin-like growth factor-I gene expression Growth Hormone & Igf Research. ,vol. 13, pp. 19- 25 ,(2003) , 10.1016/S1096-6374(02)00137-5
Rachael Dean, Stephanie R. Edmondson, Louise M. Burrell, Leon A. Bach, Localization of the Insulin-like Growth Factor System in a Rat Model of Heart Failure Induced by Myocardial Infarction: Journal of Histochemistry and Cytochemistry. ,vol. 47, pp. 649- 659 ,(1999) , 10.1177/002215549904700507
Maria Raitakari, Thomas Ilvonen, Markku Ahotupa, Terho Lehtimäki, Aimo Harmoinen, Pauli Suominen, Juhani Elo, Jaakko Hartiala, Olli T. Raitakari, Weight Reduction With Very-Low-Caloric Diet and Endothelial Function in Overweight Adults: Role of Plasma Glucose Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 24, pp. 124- 128 ,(2004) , 10.1161/01.ATV.0000109749.11042.7C
Jan-Ove Johansson, Jesper Fowelin, Kerstin Landin, Ibe Lager, Bengt-Åke Bengtsson, Growth hormone-deficient adults are insulin-resistant Metabolism-clinical and Experimental. ,vol. 44, pp. 1126- 1129 ,(1995) , 10.1016/0026-0495(95)90004-7
Marija Pfeifer, Renata Verhovec, Bogomir Zizek, Janez Prezelj, Pavel Poredos, Richard N. Clayton, Growth hormone (GH) treatment reverses early atherosclerotic changes in GH-deficient adults. The Journal of Clinical Endocrinology and Metabolism. ,vol. 84, pp. 453- 457 ,(1999) , 10.1210/JCEM.84.2.5456
Z. Laron, B. Klinger, Body Fat in Laron Syndrome Patients: Effect of Insulin-Like Growth Factor I Treatment Hormone Research in Paediatrics. ,vol. 40, pp. 16- 22 ,(1993) , 10.1159/000183762