Homocysteine: a risk factor for retinal venous occlusive disease.

作者: Bruce A Brown , Jeffrey L Marx , Thomas P Ward , Rodney D Hollifield , John S Dick

DOI: 10.1016/S0161-6420(01)00923-X

关键词:

摘要: Abstract Purpose Recent studies have shown a relationship between elevated levels of homocysteine and vascular disease including cerebrovascular accidents myocardial infarctions. We evaluated patients with recent retinal vein occlusion to determine if there was an associated elevation homocysteine. Design Age gender matched case-controlled study. Participants Twenty venous occlusive within the previous 6-month period 40 control without were enrolled in Methods history underwent laboratory testing serum levels. In addition, health survey completed several tests relating cholesterol checked. Two groups selected. The first group included diabetes no disease. second nondiabetic who also had prior Main outcome measures main parameter measured this study is fasting Results Fifteen 20 (75%) level, whereas only 5 (13%) abnormal level ( P Conclusions Patients higher homocysteine, which may serve as modifiable risk factor.

参考文章(17)
K S Mccully, Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. American Journal of Pathology. ,vol. 56, pp. 111- 128 ,(1969)
Lars Brattström, David E. L. Wilcken, John Öhrvik, Lars Brudin, Common Methylenetetrahydrofolate Reductase Gene Mutation Leads to Hyperhomocysteinemia but Not to Vascular Disease The Result of a Meta-Analysis Circulation. ,vol. 98, pp. 2520- 2526 ,(1998) , 10.1161/01.CIR.98.23.2520
Y. M. Smulders, M. Rakic, E. H. Slaats, M. Treskes, E. J. Sijbrands, D. A. Odekerken, C. D. Stehouwer, J. Silberbusch, Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and cardiovascular disease. Diabetes Care. ,vol. 22, pp. 125- 132 ,(1999) , 10.2337/DIACARE.22.1.125
Killian Robinson, Kristopher Arheart, Helga Refsum, Lars Brattström, Godfried Boers, Per Ueland, Paolo Rubba, Roberto Palma-Reis, Raymond Meleady, Leslie Daly, Jacqueline Witteman, Ian Graham, Low Circulating Folate and Vitamin B6 Concentrations Risk Factors for Stroke, Peripheral Vascular Disease, and Coronary Artery Disease Circulation. ,vol. 97, pp. 437- 443 ,(1998) , 10.1161/01.CIR.97.5.437
I. Fermo, C. Arcelloni, E. De Vecchi, S. Vigano', R. Paroni, High-performance liquid chromatographic method with fluorescence detection for the determination of total homocyst(e)ine in plasma. Journal of Chromatography A. ,vol. 593, pp. 171- 176 ,(1992) , 10.1016/0021-9673(92)80283-Z
Andrew K Vine, Hyperhomocysteinemia: a risk factor for central retinal vein occlusion. American Journal of Ophthalmology. ,vol. 129, pp. 640- 644 ,(2000) , 10.1016/S0002-9394(99)00476-6
Arlene Lobo, Arabi Naso, Kristopher Arheart, Warren D Kruger, Tariq Abou-Ghazala, Fadi Alsous, Maher Nahlawi, Anjan Gupta, Ali Moustapha, Frederick van Lente, Donald W Jacobsen, Killian Robinson, Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12 The American Journal of Cardiology. ,vol. 83, pp. 821- 825 ,(1999) , 10.1016/S0002-9149(98)01041-8
M.F. Bellamy, I.F.W. McDowell, M.W. Ramsey, M. Brownlee, C. Bones, R.G. Newcombe, M.J. Lewis, Hyperhomocysteinemia After an Oral Methionine Load Acutely Impairs Endothelial Function in Healthy Adults Circulation. ,vol. 98, pp. 1848- 1852 ,(1998) , 10.1161/01.CIR.98.18.1848