Molecular biomarkers of resistance to anti-EGFR treatment in metastatic colorectal cancer, from classical to innovation.

Fang-Hua Li, Lin Shen, Zhuang-Hua Li, Hui-Yan Luo, Miao-Zhen Qiu, Hui-Zhong Zhang, Yu-Hong Li, Rui-Hua Xu, None, Impact ofKRASmutation and PTEN expression on cetuximab-treated colorectal cancer World Journal of Gastroenterology. ,vol. 16, pp. 5881- 5888 ,(2010) , 10.3748/WJG.V16.I46.5881

Stefan Heindl, Evelyn Eggenstein, Simone Keller, Julia Kneissl, Gisela Keller, Kathrin Mutze, Sandra Rauser, Georg Gasteiger, Ingo Drexler, Alexander Hapfelmeier, Heinz Höfler, Birgit Luber, Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines Journal of Cancer Research and Clinical Oncology. ,vol. 138, pp. 843- 858 ,(2012) , 10.1007/S00432-011-1128-4

Jan Pander, Hans Gelderblom, Ninja F. Antonini, Jolien Tol, Johan H.J.M. van Krieken, Tahar van der Straaten, Cornelis J.A. Punt, Henk-Jan Guchelaar, Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-type metastatic colorectal cancer. European Journal of Cancer. ,vol. 46, pp. 1829- 1834 ,(2010) , 10.1016/J.EJCA.2010.03.017

Mohamed Hebbar, Agne`s Wacrenier, Christophe Desauw, Olivier Romano, Ste??phane Cattan, Jean-Pierre Triboulet, Francois-Rene?? Pruvot, Lack of usefulness of epidermal growth factor receptor expression determination for cetuximab therapy in patients with colorectal cancer. Anti-Cancer Drugs. ,vol. 17, pp. 855- 857 ,(2006) , 10.1097/01.CAD.0000217425.44584.9F

Wendy De Roock, Derek J. Jonker, Federica Di Nicolantonio, Andrea Sartore-Bianchi, Dongsheng Tu, Salvatore Siena, Simona Lamba, Sabrina Arena, Milo Frattini, Hubert Piessevaux, Eric Van Cutsem, Chris J. O’Callaghan, Shirin Khambata-Ford, John R. Zalcberg, John Simes, Christos S. Karapetis, Alberto Bardelli, Sabine Tejpar, Association of KRAS p.G13D Mutation With Outcome in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer Treated With Cetuximab JAMA. ,vol. 304, pp. 1812- 1820 ,(2010) , 10.1001/JAMA.2010.1535

Nicola Personeni, Steffen Fieuws, Hubert Piessevaux, Gert De Hertogh, Jef De Schutter, Bart Biesmans, Wendy De Roock, An Capoen, Maria Debiec-Rychter, Jean-Luc Van Laethem, Marc Peeters, Yves Humblet, Eric Van Cutsem, Sabine Tejpar, Clinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab : A fluorescent in situ hybridization study Clinical Cancer Research. ,vol. 14, pp. 5869- 5876 ,(2008) , 10.1158/1078-0432.CCR-08-0449

Mario Scartozzi, Alessandra Mandolesi, Riccardo Giampieri, Chiara Pierantoni, Fotios Loupakis, Alberto Zaniboni, Eva Galizia, Lucio Giustini, Rosa Rita Silva, Renato Bisonni, Rossana Berardi, Simona Biagetti, Stefano Menzo, Alfredo Falcone, Italo Bearzi, Stefano Cascinu, Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan. International Journal of Cancer. ,vol. 127, pp. 1941- 1947 ,(2010) , 10.1002/IJC.25193

Mario Scartozzi, Italo Bearzi, Alessandra Mandolesi, Chiara Pierantoni, Fotios Loupakis, Alberto Zaniboni, Francesca Negri, Antonello Quadri, Fausto Zorzi, Eva Galizia, Rossana Berardi, Tommasina Biscotti, Roberto Labianca, Gianluca Masi, Alfredo Falcone, Stefano Cascinu, Epidermal Growth Factor Receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: a fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis. BMC Cancer. ,vol. 9, pp. 303- 303 ,(2009) , 10.1186/1471-2407-9-303

F V Negri, C Bozzetti, C A Lagrasta, P Crafa, M P Bonasoni, R Camisa, G Pedrazzi, A Ardizzoni, PTEN status in advanced colorectal cancer treated with cetuximab. British Journal of Cancer. ,vol. 102, pp. 162- 164 ,(2010) , 10.1038/SJ.BJC.6605471

Carla Campanella, Marcella Mottolese, Anna Cianciulli, Angela Torsello, Roberta Merola, Isabella Sperduti, Elisa Melucci, Salvatore Conti, Maria Diodoro, Massimo Zeuli, Giancarlo Paoletti, Francesco Cognetti, Carlo Garufi, Epidermal growth factor receptor gene copy number in 101 advanced colorectal cancer patients treated with chemotherapy plus cetuximab Journal of Translational Medicine. ,vol. 8, pp. 36- 36 ,(2010) , 10.1186/1479-5876-8-36