Diagnostic significance of aquaporin-1 in liver tumors.
作者： Peter R. Mazal , Martin Susani , Fritz Wrba , Andrea Haitel
DOI: 10.1016/J.HUMPATH.2005.09.002
关键词:
摘要: The diagnostic utility of aquaporin (AQP)-1 in liver tumors was tested and compared with other well-established markers. In 30 cholangiocarcinomas (CCs), 20 hepatocellular carcinomas (HCCs), 10 metastatic colorectal (MCCs) the liver, expression AQP-1, CD10, cytokeratin (CK) 7, CK20, polyclonal carcinoembryonic antigen (pCEA) tested. addition, staining patterns CD10 pCEA were analyzed. To compare selectivity AQP-1 CK7 as possible markers for differentiated cholangiocytes, biopsies cholestatic disease also Aquaporin-1 found 93% all CCs 0% HCC (P < .000001) 30% MCC .01). positive 16.7% CC 40% .04) to 20% (not significant). Cytokeratin 7 90% 10% .00001) .0001). .0001) .00001). Canalicular observed (100% 89.5%, respectively) but typically not (0% 6.7%, never MCC. disease, expressed epithelial cells bile ducts, whereas CK7-positive hepatocytes Rappaport zone 1 did show any reactivity. Therefore, seems be a highly selective marker cholangiocytes can very helpful differential diagnosis tumors.
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