Presence of methicillin resistant Staphylococcus aureus in respiratory cultures from cystic fibrosis patients is associated with lower lung function
作者： Clement L. Ren , Wayne J. Morgan , Michael W. Konstan , Michael S. Schechter , Jeffrey S. Wagener
DOI: 10.1002/PPUL.20604
关键词:
摘要: The prevalence of methicillin resistant Staphylococcus aureus (MRSA) infections is increasing in both the general population and cystic fibrosis (CF) patients. We hypothesized that MRSA infection conductive airways as seen CF would be associated with more severe disease than sensitive S. (MSSA). To test this hypothesis, we used data from Epidemiologic Study Cystic Fibrosis (ESCF), a large observational study patients North America, to compare their respiratory tract cultures those MSSA. During 1-year time period January 1, 2001 December 31, 2001, 20,451 were collected by ESCF, 1,834 (7.5%) had positive for only. Compared MSSA only, only significantly airflow obstruction, measured forced expiratory volume 1 sec (FEV1). mean FEV1 6-17 years old was 80.7% predicted compared 89.4% group (P or=18 old. results our highlight growing clinical impact
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