The role of inflammatory and parenchymal cells in acute pancreatitis.
作者： A Vonlaufen , MV Apte , BA Imhof , JL Frossard
DOI: 10.1002/PATH.2231
关键词:
摘要: The infiltration of inflammatory cells into the pancreas is an early and central event in acute pancreatitis that promotes local injury systemic complications disease. Recent research has yielded important finding resident (particularly acinar pancreatic stellate cells) play a dynamic role leukocyte attraction via secretion chemokines cytokines expression adhesion molecules. Significant progress been made recent years our understanding movement (adhesion to blood vessel wall, transmigration through wall parenchyma) pathophysiology pancreatitis. This review discusses studies describes current state knowledge field. It clear detailed elucidation numerous processes cascade essential step towards development improved therapeutic strategies Studies date suggest combination therapy targeting different steps may be treatment choice for this
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