Genomic epidemiology cohorts in Korea: present and the future.

摘要: Human genome epidemiology involves the application of genetic technology to assess impact variations at DNA level on health and disease. Recent developments in molecular biology allow epidemiologists use biomarkers determine an individual's predisposition disease detect early stage. Moreover, advances genomics proteomics could play a central role research into prediction prevention. Large scale population-based cohort prospective studies offer most comprehensive approach delineation gene function, effects environment, their interactions. The Korean Multi-center Cancer Cohort (KMCC), under construction since 1993, is first multi-center identify risk factors for cancer Korea. Data general lifestyle, physical activity, diet, reproductive factors, agricultural exposure are obtained through direct interview using structured questionnaire. Anthropometric measurements clinical laboratory findings also collected web-based data entry system. biological materials have been banked (blood (serum, plasma, buffy coat, packed erythrocytes) stored -70 °C urine -20°C) future analysis. Several other cohorts including National Center (KNCC) Cohort, Health Examinees (KOEX) Genome Epidemiologic Study (KHGES), Yang Pyeong launched KMCC was initiated. Even though these similar biospecimen, questionnaires protocols used not standardized. However, increased scope designed cardiovascular disease, metabolic syndrome, cancer. Subjects followed up actively by personnel different regions record linkages with registry, national death certificate insurance claim databases. As August 2004, total number subjects enrolled all archived biologic specimens around 80,000. A new genomic has 2001 Korea, which target 250,000 men women over next 5 years. This article describes goals designs each above- mentioned cohorts.