Apolipophorin-III Acts as a Positive Regulator of Plasmodium Development in Anopheles stephensi.
作者： Rini Dhawan , Kuldeep Gupta , Mithilesh Kajla , Parik Kakani , Tania P. Choudhury
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摘要: Apolipophorin III (ApoLp-III) is a well-known hemolymph protein having functional role in lipid transport and immune responses of insects. Here we report the molecular characterization Anopheles stephensi Apolipophorin-III (AsApoLp-III) gene. This gene consists 679 nucleotides arranged into two exons 45 bp 540 that give an ORF encoding 194 amino acid residues. Excluding putative signal peptide first 19 residues, 175-residues mature AsApoLp-III has calculated mass 22 kDa. Phylogenetic analysis revealed divergence mosquitoes (Order Diptera) ApoLp-III from their counterparts moths (Order: Lepidoptera). Also, it close relatedness to An. gambiae. mRNA expression strongly induced Plasmodium berghei infected mosquito midguts suggesting its crucial parasite development. silencing decreased P. oocysts numbers by 7.7 fold against controls. These effects might be due interruption mediated delivery developing oocysts. In addition, nitric oxide synthase (NOS), antiplasmodial gene, also highly silenced this acts like agonist protects immunity.
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Rini Dhawan, Kuldeep Gupta, Mithilesh Kajla, Sanjeev Kumar, Surendra K. Gakhar, Parik Kakani, Tania Pal Choudhury, Lalita Gupta, Molecular characterization of SOCS gene and its expression analysis on Plasmodium berghei infection in Anopheles culicifacies Acta Tropica. ,vol. 152, pp. 170- 175 ,(2015) , 10.1016/J.ACTATROPICA.2015.09.014
Zixuan Sun, Junfeng Yu, Wenjing Wu, Guren Zhang, Molecular characterization and gene expression of apolipophorin III from the ghost moth, Thitarodes pui (Lepidoptera, Hepialidae) Archives of Insect Biochemistry and Physiology. ,vol. 80, pp. 1- 14 ,(2012) , 10.1002/ARCH.20456
Agnieszka Zdybicka-Barabas, Małgorzata Cytryńska, Involvement of apolipophorin III in antibacterial defense of Galleria mellonella larvae. Comparative Biochemistry and Physiology B. ,vol. 158, pp. 90- 98 ,(2011) , 10.1016/J.CBPB.2010.10.001
P WEERS, R RYAN, Apolipophorin III: role model apolipoprotein. Insect Biochemistry and Molecular Biology. ,vol. 36, pp. 231- 240 ,(2006) , 10.1016/J.IBMB.2006.01.001
Anna Cohuet, Parfait Awono-Ambene, Maria De Iorio, Didier Fontenille, Isabelle Morlais, George K. Christophides, Fotis C. Kafatos, Dina Vlachou, Antonio M. Mendes, Timm Schlegelmilch, Conserved Mosquito/Parasite Interactions Affect Development of Plasmodium falciparum in Africa PLoS Pathogens. ,vol. 4, pp. e1000069- ,(2008) , 10.1371/JOURNAL.PPAT.1000069
Estefanía Contreras, Carolina Rausell, M. Dolores Real, Tribolium castaneum Apolipophorin-III acts as an immune response protein against Bacillus thuringiensis Cry3Ba toxic activity Journal of Invertebrate Pathology. ,vol. 113, pp. 209- 213 ,(2013) , 10.1016/J.JIP.2013.04.002
Hong Ja Kim, Hyun Jeong Je, Shin Yong Park, In Hee Lee, Byung Rae Jin, Hwa Kyung Yun, Chi Young Yun, Yeon Soo Han, Young Jin Kang, Sook Jae Seo, Immune activation of apolipophorin-III and its distribution in hemocyte from Hyphantria cunea. Insect Biochemistry and Molecular Biology. ,vol. 34, pp. 1011- 1023 ,(2004) , 10.1016/J.IBMB.2004.05.005
Yusuke Kato, Yoshiko Motoi, Kiyoko Taniai, Keiko Kadono-Okuda, Masanori Yamamoto, Yoshiaki Higashino, Michio Shimabukuro, Subrata Chowdhury, Jinhua Xu, Masao Sugiyama, Miyako Hiramatsu, Minoru Yamakawa, Lipopolysaccharide-lipophorin complex formation in insect hemolymph: a common pathway of lipopolysaccharide detoxification both in insects and in mammals Insect Biochemistry and Molecular Biology. ,vol. 24, pp. 547- 555 ,(1994) , 10.1016/0965-1748(94)90090-6
Lalita Gupta, Alvaro Molina-Cruz, Sanjeev Kumar, Janneth Rodrigues, Rajnikant Dixit, Rodolfo E. Zamora, Carolina Barillas-Mury, The STAT Pathway Mediates Late-Phase Immunity against Plasmodium in the Mosquito Anopheles gambiae Cell Host & Microbe. ,vol. 5, pp. 498- 507 ,(2009) , 10.1016/J.CHOM.2009.04.003
Shin Yong Park, Chong Han Kim, Woo Hyuk Jeong, Joon Ha Lee, Sook Jae Seo, Yeon Soo Han, In Hee Lee, Effects of two hemolymph proteins on humoral defense reactions in the wax moth, Galleria mellonella. Developmental and Comparative Immunology. ,vol. 29, pp. 43- 51 ,(2005) , 10.1016/J.DCI.2004.06.001