Molecular characterization of SOCS gene and its expression analysis on Plasmodium berghei infection in Anopheles culicifacies

摘要: Anopheles culicifacies mosquitoes are able to transmit both falciparum and vivax malaria in India. More than 65% of cases reported annually spread through this vector. Despite the fact that it poses major vectorial burden India, molecular basis its immune role against Plasmodium development has not been explored intensively. Here, we characterized An. SOCS (suppressor cytokine signaling) gene, a regulator STAT pathway expression analysis upon infection. Our demonstrated gene shares strikingly high level sequence similarity SH2 domain box region with other mosquito species. However, N-terminal identity is limited Anophelines only, suggesting genus specific role. mRNA expressed all developmental stages higher male female adults. significantly induced after infection midgut tissue indicating involvement defense responses. This first evidence as an Indian vector culicifacies.