Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis.

摘要: In this study, we evaluated the cellular influx and cytokine environment in lungs of mice made immune by prior vaccination with Mycobacterium bovis bacillus Calmette-Guerin compared control after infection tuberculosis to characterize composition protective lesions lungs. Immune controlled growth M. challenge more efficiently than mice. animals, granulomatous were smaller had a lymphocytic core, less foamy cells, parenchymal inflammation, slower progression lung pathology During chronic stage infection, bacterial load remained at level 10 times lower mice, was associated reduced numbers CD4P(+P) CD8P(+P) T expression (IL-12, IFN-gamma), inflammatory (TNF-alpha), immunoregulatory (GM-CSF), immunosuppressive (IL-10) cytokines. The higher CD11b- CD11c(high) DEC-205(low) alveolar macrophages, but CD11b+ DEC-205(high) dendritic latter expressing significantly levels antiapoptotic marker TNFR-associated factor-1. Moreover, during early cells from expressed MHC class II CD40 molecules similar These results indicate that while disease state is eventual outcome both infected aerosol exposure, develop lesion increasing macrophage