Principles of transcriptional control in the metabolic network of Saccharomyces cerevisiae.

摘要: Cellular networks are subject to extensive regulation, which modifies the availability and efficiency of connections between components in response external conditions. Thus far, studies large-scale have focused on their connectivity, but not considered how modulation this connectivity might also determine network properties. To address issue, we analyzed coordinated expression enzymes shapes metabolic Saccharomyces cerevisiae. By integrating data with structural description network, systematically characterized transcriptional regulation pathways. The analysis revealed recurrent patterns, may represent design principles gene regulation. First, find that transcription biases flow toward linearity by coexpressing only distinct branches at branchpoints. Second, individual isozymes were often separately coregulated processes, providing a means reducing crosstalk pathways using common reaction. Finally, defined hierarchical organization into groups varying coherence. These results emphasize utility incorporating regulatory information when analyzing properties cellular networks.