Effect of age and dietary restriction on the expression of alpha 2u-globulin.
作者：
DOI: 10.1016/S0021-9258(18)45280-5
关键词:
摘要: The effect of aging on the expression alpha 2u-globulin was studied in liver tissue from 6-30-month-old male Fischer F344 rats. synthesis by suspensions isolated hepatocytes decreased 90% between 6 and 22 months age. levels mRNA transcription genes nuclei 80-85% 5 24 Because has been suggested to be a "senescence marker protein," measured rats fed diet restricted calories. This dietary restriction procedure shown increase significantly longevity rodents. compared 18-month-old ad libitum (40% total calories). synthesis, levels, were 1.8-3-fold higher for libitum. Therefore, alters age-related change 2u-globulin. Our results demonstrate that changes arise during or are regulated at level transcription.
utsystem.edu参考文章(42)
A K Roy, T S Nath, N M Motwani, B Chatterjee, Age-dependent regulation of the polymorphic forms of alpha 2u-globulin. Journal of Biological Chemistry. ,vol. 258, pp. 10123- 10127 ,(1983) , 10.1016/S0021-9258(17)44614-X
A.K. Roy, B. Chatterjee, M.S. Prasad, N.J. Unakar, Role of insulin in the regulation of the hepatic messenger RNA for alpha 2u-globulin in diabetic rats. Journal of Biological Chemistry. ,vol. 255, pp. 11614- 11618 ,(1980) , 10.1016/S0021-9258(19)70333-0
NM Motwani, Diane Caron, WF Demyan, B Chatterjee, S Hunter, MD Poulik, Arun K Roy, None, Monoclonal antibodies to alpha 2u-globulin and immunocytofluorometric analysis of alpha 2u-globulin-synthesizing hepatocytes during androgenic induction and aging. Journal of Biological Chemistry. ,vol. 259, pp. 3653- 3657 ,(1984) , 10.1016/S0021-9258(17)43145-0
Harold P. Morris, David T. Kurtz, Philip Feigelson, Albrecht E. Sippel, Comparison of in Vivo Translation Rates and Messenger RNA Levels of α2U-Globulin in Rat Liver and Morris Hepatoma 5123D Cancer Research. ,vol. 36, pp. 3588- 3593 ,(1976)
Maria C. Birchenall-Sparks, Michael S. Roberts, Jeffrey Staecker, James P. Hardwick, Arlan Richardson, Effect of dietary restriction on liver protein synthesis in rats. Journal of Nutrition. ,vol. 115, pp. 944- 950 ,(1985) , 10.1093/JN/115.7.944
David T. Kurtz, Philip Feigelson, Kwok-Ming Chan, Glucocorticoid induction of hepatic alpha2u-globulin synthesis and messenger RNA level in castrated male rats in vivo. Journal of Biological Chemistry. ,vol. 253, pp. 7886- 7890 ,(1978) , 10.1016/S0021-9258(17)34454-X
B. Chatterjee, T.S. Nath, A.K. Roy, Differential regulation of the messenger RNA for three major senescence marker proteins in male rat liver. Journal of Biological Chemistry. ,vol. 256, pp. 5939- 5941 ,(1981) , 10.1016/S0021-9258(19)69103-9
Benjamin N. Berg, Nutrition and longevity in the rat. I. Food intake in relation to size, health and fertility. Journal of Nutrition. ,vol. 71, pp. 242- 254 ,(1960) , 10.1093/JN/71.3.242
PH O'Farrell, High resolution two-dimensional electrophoresis of proteins. Journal of Biological Chemistry. ,vol. 250, pp. 4007- 4021 ,(1975) , 10.1016/S0021-9258(19)41496-8
Edward J. Masoro, Nutrition and aging: a current assessment Journal of Nutrition. ,vol. 115, pp. 842- 848 ,(1985) , 10.1093/JN/115.7.842