Effect of dietary restriction on liver protein synthesis in rats.

摘要: At 6 wk of age, male Fischer F344 rats were fed a purified, casein-based diet either ad libitum or in the amount 60% consumed by (restricted diet). Hepatocytes isolated from between 2.5 and 19 mo age. The protein content hepatocytes restricted was significantly lower than that libitum. DNA RNA similar for two dietary regimens. absolute rate synthesis decreased 55% However, only slightly with increasing higher Therefore, restriction retards age-related decline liver synthesis.