Radiotherapy versus best supportive care in patients with brain metastases and adverse prognostic factors

摘要: Several previous studies have suggested that patients with brain metastases should be treated individualized approaches taking into account prognostic factors influence survival. Whether or not radiotherapy represents overtreatment in adverse features is currently being addressed the randomized QUARTZ trial (best supportive care (BSC) vs. whole (WBRT)). However, inclusion limited to primary non-small cell lung cancer. Therefore, we analyzed a broader patient population different tumors managed BSC WBRT (intended total dose 20 30 Gy). Survival was examined by uni- and multivariate analyses including matched pairs. Median overall survival of all 113 2 months. No significant difference between Gy observed. A slight but improvement observed group (median 2.2 1.7 months). The magnitude clinically meaningful. Subgroup revealed improved after small In conclusion, these results confirm extent interim from trial, suggesting reasonable choice expectation. Further efforts are necessary improve identification who likely benefit WBRT, e.g. refining available prediction tools, management those cancer include less restricted use WBRT.