Brain metastases from colorectal carcinoma. The long term survivors.

摘要: BACKGROUND Brain metastases occur in 25% to 35% of all cancer patients, with colorectal carcinoma accounting for approximately 8% these. Information about patients brain from is limited, the largest previous series reporting only 40 patients. To date there have been no reports describing subgroup long term survival (>1 yr). METHODS A retrospective review 150 seen at Mayo Clinic between 1976 and 1993 pathologic (56) and/or radiographic (94) confirmation presented. RESULTS The majority (82%) concomitant extracerebral metastases, especially lungs. Only 16% survived > 1 year after diagnosis (4 4 yrs., 2 10 yrs). Of these, 92% had single cerebral 38% systemic metastases. In addition, young age absence bony or memory loss were associated increased survival. Median receiving surgery radiotherapy (39), alone (11), (79) supportive care (17) are 42, 45, 16, 8 weeks, respectively. Thirty percent treated showed regression their tumors on follow-up head scans; three complete regression. CONCLUSIONS One-year survivors uncommon, most these (92%) solitary lesions. Nineteen 24 surgical resection as part treatment. Given similar results plus those alone, well potential side effects radiotherapy, withholding possibility should be considered. Cancer 1996;78:711-6.