Role of p21WAF1 in the cellular response to UV.

摘要: UV or g irradiation mediated DNA damage activates p53 and induces cell cycle arrest. Induction of cyclin dependent kinase inhibitor p21WAF1 by after plays an important role in arrest gamma irradiation. The has been postulated to allow cells repair the damage. Repair damaged occurs primarily nucleotide excision pathway (NER). It is known that binds PCNA inhibits function replication. also required for NER but there have conflicting reports on whether can inhibit NER. therefore difficult integrate induced p21 context DNA. A recent study reported protein degraded low not high doses irradiation, independent, at dose degradation essential optimal repair. These findings shed new light cellular response clarify some outstanding issues concerning function.