Synthesis of Water-Dispersible Mn2+ Functionalized Silicon Nanoparticles under Room Temperature and Atmospheric Pressure for Fluorescence and Magnetic Resonance Dual-Modality Imaging

摘要: Silicon nanoparticles (Si NPs) have been widely used in fluorescence imaging. However, rigorous synthesis conditions and the single modality imaging limit further development of Si NPs field biomedical Here, we reported a method for synthesizing water-dispersible Mn2+ functionalized (Mn–Si under mild experimental magnetic resonance dual-modality The whole process was completed room temperature atmospheric pressure, no special expensive equipment required. synthetic nanoparticles, with favorable pH stability, NaCl photostability, low toxicity, emitted green (512 nm). At same time, also demonstrated excellent ability. In vitro, their T1-weighted effect obvious, value longitudinal relaxation degree r1 reached 4.25 mM–1 s–1. On basis good biocompatibility, Mn–Si wer...