Nipah encephalitis outbreak in Malaysia, clinical features in patients from Seremban

作者: Heng Thay Chong , Sree Raman Kunjapan , Tarmizi Thayaparan , Jenny May Geok Tong , Vijayasingham Petharunam

DOI: 10.1017/S0317167100001785

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摘要: Introduction: Il y a eu une eclosion d'encephalite virale chez les travailleurs de l'industrie du porc en Malaisie septembre 1998 avril 1999. L'encephalite ete attribuee un nouveau paramyxovirus, le virus Nipah. Cet article decrit caracteristiques cliniques et facteurs pronostiques 103 patients traites l'Hopital Seremban. Methodes: Les dossiers rapports laboratoire ont revises. cas etaient definis comme suit: patient provenant la region touchee, contact direct ou voisinage immediat avec des porcs, selon clinique l'analyse LCR. Resultats: L'âge moyen etait 38 ans, 89% hommes. 58% d'ethnie chinoise, 78% proprietaires porcine. La periode d'incubation moyenne 10 jours. Le type consultait pour symptomes systemiques non specifiques tels l'hyperthermie, cephalee, myalgies mal george. Des convulsions signes neurologiques focaux observes 16% 5% respectivement. Dans plus severes, ces suivis somnolence d'une deterioration l'etat conscience necessitant ventilation assistee 61%. troubles neurovegetatifs secousses myocloniques frequemment observes. mortalite elevee, soit 41%. Une hypertension systolique, tachycardie forte fievre associees mauvais pronostic. D'autre part, 40% recupere completement. Chez 19%, residuels plutot legers. Conclusion: Nipah cause encephalite dont courte elevee. pronostic survivants bon.

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